ZFIN Image: Feldner et al., 2005, Fig. 2

Image

Figure Caption

Fig. 2 Neuropilin-1a (NRP1a) morpholinos induce aberrations of primary motor nerves. A-F: Lateral views of anti-tubulin-labeled whole-mounted 24 hpf embryos at mid-trunk levels are shown (rostral is left). A,B: In uninjected embryos (A) or those injected with 1 mM NRP1a 4mm morpholino (4mm, B), single unbranched motor nerves (arrows in A,B) grow ventrally out of the spinal cord. C-E: Injection of 1 mM NRP1a morpholino1 induced branching (arrows in C), a second exit point for motor axons per hemisegment (arrows in D), or anti-tubulin-labeled cells that appear to have migrated out of the spinal cord along the pathway of the ventral motor nerve (arrows in E). F: Injection of 1 mM NRP1a morpholino2 also induced aberrant branching (arrow) of the ventral motor nerve. Scale bar = 25 μm in F (applies to A-F).

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