Gene
tcf7l1b
- ID
- ZDB-GENE-991110-10
- Name
- transcription factor 7 like 1b
- Symbol
- tcf7l1b Nomenclature History
- Previous Names
-
- tcf3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell proliferation in dorsal spinal cord; endothelial cell fate specification; and nervous system development. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in chromatin. Is expressed in nervous system; optic vesicle; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009071 | High mobility group box domain |
| Domain | IPR013558 | CTNNB1 binding, N-teminal |
| Family | IPR024940 | Transcription factor TCF/LEF |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
| Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q800Q5 | InterPro | 551 | |||||
| UniProtKB:F1R336 | InterPro | 550 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tcf7l1b-201
(1)
|
Ensembl | 4,356 nt | ||
| mRNA |
tcf7l1b-202
(1)
|
Ensembl | 3,042 nt | ||
| mRNA |
tcf7l1b-203
(1)
|
Ensembl | 1,040 nt | ||
| mRNA |
tcf7l1b-204
(1)
|
Ensembl | 3,711 nt | ||
| mRNA |
tcf7l1b-205
(1)
|
Ensembl | 4,461 nt |
1 - 5 of 5
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-233G2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-155H12 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-354H10 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-360A7 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-459D16 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-467B24 | ZFIN Curated Data |
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