Gene
aanat2
- ID
- ZDB-GENE-991019-6
- Name
- arylalkylamine N-acetyltransferase 2
- Symbol
- aanat2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables acetyltransferase activity. Acts upstream of or within several processes, including neutrophil chemotaxis; photoperiodism; and positive regulation of circadian sleep/wake cycle, sleep. Predicted to be active in cytoplasm. Is expressed in brain; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73039 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aanat2 | Ren et al., 2017 | |
| CRISPR2-aanat2 | Zebrafish Nomenclature Committee | |
| TALEN1-aanat2 | (8) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA N-acyltransferase | GNAT domain | Serotonin N-acetyltransferase-like |
|---|---|---|---|---|---|
| UniProtKB:Q9PVD7 | InterPro | 209 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aanat2-201
(1)
|
Ensembl | 1,446 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(aanat2:CFP-NTR) |
|
| 1 | (2) | |
| Tg(aanat2:EGFP) |
|
| 3 | (26) | |
| Tg(aanat2:EGFP-2A-Dclocka-5xMYC) |
|
| 1 | (3) | |
| Tg(aanat2:GAL4-VP16) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(aanat2:mRFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-155C19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-233G21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-189N21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73039 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86582 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131411 (1) | 1446 nt | ||
| Genomic | GenBank:AL928800 | 153880 nt | ||
| Polypeptide | UniProtKB:Q9PVD7 (1) | 209 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Ding, H., Chen, X.C., Wan, L., Zhang, Y.Y., Rui, X.H., He, T., Liu, J., Shang, Z.B. (2024) Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues. Heliyon. 10:e30829e30829
- Lee, J.H., Hwang, S.J., Ham, S.L., Kim, J., Bang, H.J., Park, J.S., Jang, H.H., Kim, T.Y., Park, J.W., Seo, Y.R., Kim, B.S., Kim, G.S., Lee, H.J., Kim, C.S. (2024) Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice. ACS omega. 9:438754388343875-43883
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Carstensen, M.B., Medvetzky, A., Weinberger, A., Driever, W., Gothilf, Y., Rath, M.F. (2022) Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior. Journal of pineal research. 72(4):e12795
- Confino, S., Dor, T., Tovin, A., Wexler, Y., Ben-Moshe Livne, Z., Kolker, M., Pisanty, O., Park, S.K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N.S., Gothilf, Y. (2022) A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System. International Journal of Molecular Sciences. 23(4):
- D'Agostino, Y., Frigato, E., Noviello, T.M.R., Toni, M., Frabetti, F., Cigliano, L., Ceccarelli, M., Sordino, P., Cerulo, L., Bertolucci, C., D'Aniello, S. (2022) Loss of circadian rhythmicity in bdnf knockout zebrafish larvae. iScience. 25:104054
- Dekens, M.P.S., Fontinha, B.M., Gallach, M., Pflügler, S., Tessmar-Raible, K. (2022) Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish. EMBO reports. 23(5):e51528
- Sua-Cespedes, C.D., David, D.D., Souto-Neto, J.A., Lima, O.G., Moraes, M.N., de Assis, L.V.M., Castrucci, A.M.L. (2021) Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio. Frontiers in Physiology. 12:707067
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