Gene

tbx2a

ID
ZDB-GENE-990917-4
Name
T-box transcription factor 2a
Symbol
tbx2a Nomenclature History
Previous Names
  • tbx-a
  • tbxa
  • zgc:85705
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including enteric nervous system development; heart development; and kidney development. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including digestive system; mesoderm; nervous system; pericardial region; and pronephros. Human ortholog(s) of this gene implicated in atrial heart septal defect; heart septal defect; and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
26 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tbx2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vertebral anomalies and variable endocrine and T-cell dysfunction Alliance Vertebral anomalies and variable endocrine and T-cell dysfunction 618223
1 - 1 of 1
Associated With tbx2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018186 Transcription factor, T-box, conserved site
Domain IPR022582 T-box transcription factor 2/3, transcription activation domain
Domain IPR046360 T-box transcription factor, DNA-binding domain
Domain IPR048387 T-box transcription factor 2/3, repressor domain
Family IPR001699 T-box transcription factor
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length p53-like transcription factor, DNA-binding domain superfamily T-box superfamily T-box transcription factor T-box transcription factor 2/3, repressor domain T-box transcription factor 2/3, transcription activation domain T-box transcription factor, DNA-binding domain Transcription factor, Brachyury Transcription factor, T-box, conserved site
UniProtKB:B0R122 InterPro 686
UniProtKB:A0A8M2BCU2 InterPro 690
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tbx2a-201 (1) Ensembl 5,470 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations