Gene

sema4e

ID

ZDB-GENE-990715-7

Name

semaphorin 4e

Symbol

sema4e Nomenclature History

Previous Names

sema7
semaZ7

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including negative regulation of axon extension involved in axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to localize to extracellular space and integral component of plasma membrane. Is expressed in central nervous system; pectoral fin bud; and pharyngeal arch. Orthologous to human SEMA4D (semaphorin 4D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Halloran et al., 1998

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sema4e Human Ortholog

No data available

Associated With sema4e Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001627	Sema domain
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR016201	PSI domain
Family	IPR027231	Semaphorin
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036352	Sema domain superfamily
Repeat	IPR002165	Plexin repeat

Domain Details Per Protein

Protein	Length	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Plexin repeat	PSI domain	Sema domain	Sema domain superfamily	Semaphorin	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q9YHX4 InterPro	766
UniProtKB:F1QNC4 InterPro	766
UniProtKB:A4JYS3 InterPro	766
UniProtKB:Q1MT68 InterPro	766

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sema4e-202 (1) Ensembl	Havana	2619 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	sema4e-203 (1) Ensembl	Havana	2918 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations