ZFIN is now using GRCz12tu for Genomic Data
Gene
frzb
- ID
- ZDB-GENE-990715-1
- Name
- frizzled related protein
- Symbol
- frzb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within chondrocyte proliferation and vasculature development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including corpuscles of Stannius; germ ring; head; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb291 (37 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Osteoarthritis susceptibility 1} | 165720 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001134 | Netrin domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR020067 | Frizzled domain |
| Domain | IPR035813 | Secreted frizzled-related protein 3, NTR domain |
| Domain | IPR041759 | SFRP3, cysteine-rich domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Netrin domain | Netrin module, non-TIMP type | Secreted frizzled-related protein 3, NTR domain | SFRP3, cysteine-rich domain | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W6E0 | InterPro | 315 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers