ZFIN is now using GRCz12tu for Genomic Data
Gene
foxo3b
- ID
- ZDB-GENE-990708-6
- Name
- forkhead box O3b
- Symbol
- foxo3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to be active in nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including immune system; muscle; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu663 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032067 | FOXO protein, transactivation domain |
| Domain | IPR032068 | FOXO protein, KIX-binding domain |
| Domain | IPR047408 | Forkhead box protein O1, forkhead domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein O1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXO protein, KIX-binding domain | FOXO protein, transactivation domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9W7F8 | InterPro | 651 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxo3b-201
(1)
|
Ensembl | 4,540 nt |
Interactions and Pathways
Plasmids
No data available
- Genome Browsers