Gene
svila
- ID
- ZDB-GENE-990706-5
- Name
- supervillin a
- Symbol
- svila Nomenclature History
- Previous Names
-
- svil
- sb:cb867
- wu:fd05a09
- zmp:0000000648 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; optic vesicle; and sensory system. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb867 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Deo et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myofibrillar myopathy 10 | Alliance | Myofibrillar myopathy 10 | 619040 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADF-H/Gelsolin-like domain superfamily | Gelsolin-like domain | Villin/Gelsolin | Villin headpiece | Villin headpiece domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q864 | InterPro | 2239 | |||||
| UniProtKB:A0A8M9QII8 | InterPro | 2264 | |||||
| UniProtKB:A0A8M9QE30 | InterPro | 2208 | |||||
| UniProtKB:A0A8M9PW23 | InterPro | 2241 | |||||
| UniProtKB:A0A8M9QIJ4 | InterPro | 1847 | |||||
| UniProtKB:A0A8M9QMC6 | InterPro | 1919 | |||||
| UniProtKB:Q38HW9 | InterPro | 1763 | |||||
| UniProtKB:F1Q6K8 | InterPro | 1763 | |||||
| UniProtKB:A0AB13ABN4 | InterPro | 2264 | |||||
| UniProtKB:A0AB32TYD5 | InterPro | 1840 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
svila-207
(1)
|
Ensembl | 750 nt | ||
| mRNA |
svila-201
(1)
|
Ensembl | 6,407 nt | ||
| mRNA |
svila-202
(1)
|
Ensembl | 511 nt | ||
| mRNA |
svila-203
(1)
|
Ensembl | 2,851 nt | ||
| mRNA |
svila-204
(1)
|
Ensembl | 553 nt | ||
| mRNA |
svila-205
(1)
|
Ensembl | 896 nt | ||
| mRNA |
svila-208
(1)
|
Ensembl | 8,812 nt | ||
| mRNA |
svila-209
(1)
|
Ensembl | 8,791 nt | ||
| ncRNA |
svila-005
(1)
|
Ensembl | 378 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance