ZFIN is now using GRCz12tu for Genomic Data
Gene
serpinh1b
- ID
- ZDB-GENE-990415-93
- Name
- serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
- Symbol
- serpinh1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within fin regeneration. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including ectoderm; fin; germ ring; mesenchyme derived from head mesoderm; and mesoderm. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Orthologous to human SERPINH1 (serpin family H member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb216 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bhadra et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019300Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-serpinh1b | (2) | |
| CRISPR3-serpinh1b | (2) | |
| CRISPR4-serpinh1b | (2) | |
| MO1-serpinh1b | N/A | Bhadra et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 10 | Alliance | Osteogenesis imperfecta, type X | 613848 |
| preterm premature rupture of the membranes | Alliance | {Preterm premature rupture of the membranes, susceptibility to} | 610504 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QQ04 | InterPro | 405 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpinh1b-201
(1)
|
Ensembl | 2,084 nt | ||
| mRNA |
serpinh1b-202
(1)
|
Ensembl | 3,295 nt | ||
| mRNA |
serpinh1b-204
(1)
|
Ensembl | 848 nt | ||
| ncRNA |
serpinh1b-003
(1)
|
Ensembl | 804 nt | ||
| ncRNA |
serpinh1b-004
(1)
|
Ensembl | 1,130 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-52L18 | ZFIN Curated Data | |
| Encodes | EST | cb216 | Thisse et al., 2001 | |
| Encodes | EST | fc56b02 | ||
| Encodes | EST | ibd5060 | ||
| Encodes | cDNA | MGC:86594 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131204 (1) | 2047 nt | ||
| Genomic | GenBank:BX537138 (2) | 144274 nt | ||
| Polypeptide | UniProtKB:F1QQ04 (1) | 405 aa |
- Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):
- Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914
- Torraca, V., White, R.J., Sealy, I.M., Mazon-Moya, M., Duggan, G., Willis, A., Busch-Nentwich, E.M., Mostowy, S. (2023) Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri. Disease models & mechanisms. 17(1):
- Fujii, K.K., Taga, Y., Takagi, Y.K., Masuda, R., Hattori, S., Koide, T. (2022) The Thermal Stability of the Collagen Triple Helix Is Tuned According to the Environmental Temperature. International Journal of Molecular Sciences. 23(4):
- Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):
- Wang, C., Zhang, X., Wang, X., Zhai, Y., Li, M., Pan, J., Bai, Y., Rong, X., Zhou, J. (2022) Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development. Journal of Cell Science. 135(21):
- Li, F., Long, Y., Xie, J., Ren, J., Zhou, T., Song, G., Li, Q., Cui, Z. (2021) Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress. International Journal of Molecular Sciences. 22(11):
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Lacave, J.M., Bilbao, E., Gilliland, D., Mura, F., Dini, L., Cajaraville, M.P., Orbea, A. (2019) Bioaccumulation, cellular and molecular effects in adult zebrafish after exposure to cadmium sulphide nanoparticles and to ionic cadmium. Chemosphere. 238:124588
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
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