Gene

hoxa13a

ID

ZDB-GENE-990415-5

Name

homeobox A13a

Symbol

hoxa13a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within fin development and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; gut; notochord; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in Guttmacher syndrome and hand-foot-genital syndrome. Orthologous to human HOXA13 (homeobox A13).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hoxa13a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Guttmacher syndrome	Alliance	?Guttmacher syndrome	176305
hand-foot-genital syndrome	Alliance	Hand-foot-uterus syndrome	140000

Associated With hoxa13a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR022067	Homeobox protein Hox1A3 N-terminal
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily