Gene
hoxa13a
- ID
- ZDB-GENE-990415-5
- Name
- homeobox A13a
- Symbol
- hoxa13a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within fin development and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; gut; pectoral fin; pectoral fin bud; and tail bud. Human ortholog(s) of this gene implicated in Guttmacher syndrome and hand-foot-genital syndrome. Orthologous to human HOXA13 (homeobox A13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Guttmacher syndrome | Alliance | ?Guttmacher syndrome | 176305 |
| hand-foot-genital syndrome | Alliance | Hand-foot-genital syndrome | 140000 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anterior-posterior axis regulatory homeobox | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein Hox1A3 N-terminal | Homeodomain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A3KNK0 | InterPro | 310 | |||||
| UniProtKB:Q6W990 | InterPro | 310 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxa13a-201
(1)
|
Ensembl | 1,669 nt |
Interactions and Pathways
No data available
Plasmids