Gene

bfb

ID
ZDB-GENE-990415-34
Name
complement component bfb
Symbol
bfb Nomenclature History
Previous Names
  • Bf-2 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation and response to bacterium. Predicted to be located in extracellular region. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa7248Allele with one point mutationUnknownSplice SiteENU
sa11825Allele with one point mutationUnknownSplice SiteENU
sa18010Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With bfb Human Ortholog
No data available
Associated With bfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR002035 von Willebrand factor, type A
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily von Willebrand factor A-like domain superfamily von Willebrand factor, type A
UniProtKB:Q6DHC4 InterPro 456
UniProtKB:A0A8M9PTN0 InterPro 448
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bfb-201 (1) Ensembl 1,671 nt
ncRNA bfb-002 (1) Ensembl 774 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-197A18ZFIN Curated Data
EncodescDNAMGC:92519ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
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