Gene
rx3
- ID
- ZDB-GENE-990415-238
- Name
- retinal homeobox gene 3
- Symbol
- rx3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development and cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Orthologous to human RAX (retina and anterior neural fold homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 81 figures from 49 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, isolated 3 | 611038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|
|
UniProtKB:O42358
|
292 | |||||
|
UniProtKB:A8E7H4
|
292 |
Interactions and Pathways
No data available
Plasmids
No data available