Gene
rx3
- ID
- ZDB-GENE-990415-238
- Name
- retinal homeobox gene 3
- Symbol
- rx3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including camera-type eye development; diencephalon development; and neural crest cell migration. Predicted to be located in nucleus. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Orthologous to human RAX (retina and anterior neural fold homeobox).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 86 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, syndromic 16 | 611038 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42358 | InterPro | 292 |
Interactions and Pathways
No data available
Plasmids
No data available