Gene
fzd2
- ID
- ZDB-GENE-990415-224
- Name
- frizzled class receptor 2
- Symbol
- fzd2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Localizes to plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia. Orthologous to human FZD2 (frizzled class receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb383 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| omodysplasia 2 | Alliance | Omodysplasia 2 | 164745 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000539 | Frizzled/Smoothened, transmembrane domain |
| Domain | IPR017981 | GPCR, family 2-like |
| Domain | IPR020067 | Frizzled domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Family | IPR026550 | Frizzled-1/2 |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Length | Frizzled-1/2 | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, transmembrane domain | GPCR, family 2-like |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90YL7
|
550 | ||||||
|
UniProtKB:F1QBI2
|
550 | ||||||
|
UniProtKB:Q90449
|
123 |
Interactions and Pathways
No data available
Plasmids
No data available