Gene
fzd5
- ID
- ZDB-GENE-990415-218
- Name
- frizzled class receptor 5
- Symbol
- fzd5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables Wnt receptor activity. Involved in eye development and non-canonical Wnt signaling pathway. Acts upstream of or within several processes, including liver development; negative regulation of canonical Wnt signaling pathway; and swim bladder development. Predicted to be located in several cellular components, including Golgi membrane; dendrite; and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Used to study coloboma. Orthologous to human FZD5 (frizzled class receptor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb631 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb632 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa31718 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31719 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sdu4 | Allele with one deletion | Exon 1 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fzd5 | Zebrafish Nomenclature Committee | |
| MO1-fzd5 | N/A | (5) |
| MO2-fzd5 | N/A | (2) |
| MO3-fzd5 | N/A | Liu et al., 2016 |
| TALEN1-fzd5 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Microphthalmia/coloboma 11 | 620731 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | AB + MO3-fzd5 | standard conditions | Liu et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|
| UniProtKB:B3DIG4 | InterPro | 592 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-226M24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194936 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194943 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131134 (1) | 1923 nt | ||
| Genomic | GenBank:FQ377896 (1) | 40432 nt | ||
| Polypeptide | UniProtKB:B3DIG4 (1) | 592 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Momoi, et al. (2003. Mech. Dev. 120:477-489.) reported this gene as fz8c with orthology to human FZD8 and mouse Fzd8 based on amino acid similarity. Subsequent analysis suggests this gene is fzd5 with orthology to human FZD5 and mouse Fzd5 based on amino acid similarity and conserved location.
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Cortés-González, V., Rodriguez-Morales, M., Ataliotis, P., Mayer, C., Plaisancié, J., Chassaing, N., Lee, H., Rozet, J.M., Cavodeassi, F., Fares Taie, L. (2024) Homozygosity for a hypomorphic mutation in frizzled class receptor 5 causes syndromic ocular coloboma with microcornea in humans. Human genetics. 143(12):1509-1521
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Sharma, S., Kumar, M., Kumar, J., Srivastava, N., Hussain, M.A., Shelly, A., Mazumder, S. (2021) M. fortuitum-induced CNS-pathology: Deciphering the role of canonical Wnt signaling, blood brain barrier components and cytokines. Developmental and comparative immunology. 122:104111
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
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