Gene

fzd4

ID
ZDB-GENE-990415-217
Name
frizzled class receptor 4
Symbol
fzd4 Nomenclature History
Previous Names
  • fz1
  • zg01
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within retina homeostasis and retina vasculature development in camera-type eye. Predicted to be active in plasma membrane. Is expressed in central nervous system; neural plate; and neurogenic placode. Used to study exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Caceres et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fzd4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
exudative vitreoretinopathy 1 Alliance Exudative vitreoretinopathy 1 133780
exudative vitreoretinopathy 1 Alliance Retinopathy of prematurity 133780
Associated With fzd4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026551 Frizzled-4
Domain Details Per Protein
Protein Length Frizzled-4 Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like
UniProtKB:A0A0R4IVK2 523
UniProtKB:Q90442 85
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations