Gene
hbba1
- ID
- ZDB-GENE-990415-18
- Name
- hemoglobin, beta adult 1
- Symbol
- hbba1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within response to hypoxia. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in brain; eye; hematopoietic system; kidney; and vasculature. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63973 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Globin | Globin-like superfamily | Globin/Protoglobin | Hemoglobin and related oxygen transporters | Hemoglobin, beta-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q90486 | InterPro | 148 | |||||
| UniProtKB:B3DG37 | InterPro | 148 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-5K11 | ZFIN Curated Data | |
| Contained in | BAC | XX-BY187G17 | ||
| Contained in | PAC | BUSM1-118J2 | ||
| Encodes | cDNA | MGC:63973 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92900 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:123164 | ||
| Encodes | cDNA | MGC:136512 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152838 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193846 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193857 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131020 (1) | 645 nt | ||
| Genomic | GenBank:AL953863 (1) | 163814 nt | ||
| Polypeptide | UniProtKB:B3DG37 (1) | 148 aa |
No data available
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Lin, J., Li, X., Lu, K., Song, K., Wang, L., Dai, W., Mohamed, M., Zhang, C. (2024) Low phosphorus causes hepatic energy metabolism disorder through Dynamin-related protein 1-mediated mitochondrial fission in fish. The Journal of nutrition. 155(1):132-152
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Basheer, F., Lee, E., Liongue, C., Ward, A.C. (2022) Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation. Biomolecules. 12(10):
- Ragsdale, A., Ortega-Recalde, O., Dutoit, L., Besson, A.A., Chia, J.H.Z., King, T., Nakagawa, S., Hickey, A., Gemmell, N.J., Hore, T., Johnson, S.L. (2022) Paternal hypoxia exposure primes offspring for increased hypoxia resistance. BMC Biology. 20:185
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