Gene
nkx2.7
- ID
- ZDB-GENE-990415-179
- Name
- NK2 transcription factor related 7
- Symbol
- nkx2.7 Nomenclature History
- Previous Names
-
- nk2.7
- nkx2-7
- zgc:100762
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in heart development and regulation of cardiac chamber formation. Predicted to localize to nucleus. Is expressed in heart primordium and lateral plate mesoderm. Orthologous to human NKX2-6 (NK2 homeobox 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| double outlet right ventricle | Alliance | Conotruncal heart malformations | 217095 |
| double outlet right ventricle | Alliance | Persistent truncus arteriosus | 217095 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox domain, metazoa | Homeobox-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q98873
|
269 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
nkx2.7-201
(1)
|
Havana | 1176 nt |
Interactions and Pathways
No data available
Plasmids
No data available