Gene

ngfa

ID
ZDB-GENE-990415-176
Name
nerve growth factor a (beta polypeptide)
Symbol
ngfa Nomenclature History
Previous Names
  • etID309941.23 (1)
  • nt7
  • ntf6/7 (1)
  • ntf7
  • znt7
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to be located in extracellular region. Predicted to be active in synaptic vesicle. Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ngfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 5 Alliance Neuropathy, hereditary sensory and autonomic, type V 608654
Associated With ngfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019846 Nerve growth factor conserved site
Domain IPR002072 Nerve growth factor-related
Family IPR020408 Nerve growth factor-like
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Nerve growth factor conserved site Nerve growth factor-like Nerve growth factor-related
UniProtKB:B3DG61 233
UniProtKB:O73797 233
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations