ntn1b

ID

ZDB-GENE-990415-168

Name

netrin 1b

Symbol

ntn1b Nomenclature History

Previous Names

net1 (1)
ntn1
etID309922.3 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Acts upstream of or within neuron projection development and regulation of axon extension. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including central nervous system; forebrain neural rod; head; hypochord; and neural plate. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

30 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zhang et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ntn1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mirror movements 4	Alliance	Mirror movements 4	618264

Associated With ntn1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001134	Netrin domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR008211	Laminin, N-terminal
Domain	IPR018933	Netrin module, non-TIMP type
Family	IPR050440	Laminin/Netrin Extracellular Matrix
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold