Gene
ntn1b
- ID
- ZDB-GENE-990415-168
- Name
- netrin 1b
- Symbol
- ntn1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Acts upstream of or within neuron projection development and regulation of axon extension. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including central nervous system; forebrain neural rod; head; hypochord; and neural plate. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhang et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mirror movements 4 | 618264 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Galactose-binding-like domain superfamily | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain | Netrin domain | Netrin module, non-TIMP type | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QUK5 | InterPro | 602 | |||||||
| UniProtKB:O42203 | InterPro | 602 |
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- Genome Browsers
Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-21H4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194828 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130998 (1) | 1809 nt | ||
| Genomic | GenBank:BX120006 (1) | 196854 nt | ||
| Polypeptide | UniProtKB:F1QUK5 (1) | 602 aa |
- Lusk, S., LaPotin, S., Presnell, J.S., Kwan, K.M. (2024) Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Dang, P., Barnes, D.T., Cheng, R.P., Xu, A., Ji Moon, Y., Sripad Kodukula, S., Raper, J.A. (2022) Netrins and netrin receptors are essential for normal targeting of sensory axons in the zebrafish olfactory bulb. Neuroscience. 508:19-29
- Kikel-Coury, N.L., Green, L.A., Nichols, E.L., Zellmer, A.M., Pai, S., Hedlund, S.A., Marsden, K., Smith, C.J. (2021) Pioneer axons utilize a dcc signaling-mediated invasion brake to precisely complete their pathfinding odyssey. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(31):6617-6636
- Nittoli, V., Fortunato, A.E., Fasano, G., Coppola, U., Gentile, A., Maiella, S., Langellotto, F., Porreca, I., De Paolo, R., Marino, R., Fiengo, M., Donizetti, A., Aniello, F., Kondo, T., Ristoratore, F., Canzoniero, L.M.T., Duboule, D., Wilson, S.W., Sordino, P. (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene X. 2:100011
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cheng, R., Jia, Y., Dai, L., Liu, C., Wang, J., Li, G., Yu, L. (2017) Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 192:7-15
- Eve, A.M.J., Smith, J.C. (2017) Knockdown of Laminin gamma-3 (Lamc3) impairs motoneuron guidance in the zebrafish embryo. Wellcome open research. 2:111
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