Gene
mhc2dcb
- ID
- ZDB-GENE-990415-143
- Name
- major histocompatibility complex class II DCB gene
- Symbol
- mhc2dcb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1).
- Genome Resources
- Note
-
novel protein similar to major histocompatibility complex class II DCB gene (mhc2dcb), MHC2DBC related sequence (mhc2dbc-rs)
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
- No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | mhc2dcb-001 (1) | Havana | 730 nt | ||
| mRNA |
mhc2dcb-201
(1)
|
Ensembl | 735 nt | ||
| mRNA | si:busm1-228j01.4-001 (1) | Havana | 735 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- McConnell, S.C., Hernandez, K.M., Andrade, J., de Jong, J.L.O. (2023) Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Scientific Reports. 13:77777777
- Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979
- Wu, X.M., Hu, Y.W., Xue, N.N., Ren, S.S., Chen, S.N., Nie, P., Chang, M.X. (2017) Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Developmental and comparative immunology. 68:58-68
- Kavaliauskis, A., Arnemo, M., Speth, M.T., Lagos, L., Rishovd, A.L., Estepa, A., Griffiths, G., Gjøen, T. (2016) Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Developmental and comparative immunology. 61:248-57
- Sun, Z., Shen, B., Wu, H., Zhou, X., Wang, Q., Xiao, J., Zhang, Y. (2015) The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish & shellfish immunology. 46(2):638-47
- Zhang, Z.-H., Wu, H.-Z., Xiao, J.-F., Wang, Q.-Y., Liu, Q., Zhang, Y.-X. (2014) Booster vaccination with live attenuated Vibrio anguillarum elicits strong protection despite weak specific antibody response in zebrafish. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 30(1):117-120
- Dijkstra, J.M., Grimholt, U., Leong, J., Koop, B.F., and Hashimoto, K. (2013) Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. BMC Evolutionary Biology. 13:260
- Hess, I., Iwanami, N., Schorpp, M., and Boehm, T. (2013) Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 110(11):4327-32
- Zhang, Z., Wu, H., Xiao, J., Wang, Q., Liu, Q., and Zhang, Y. (2013) Immune responses evoked by infection with Vibrio anguillarum in zebrafish bath-vaccinated with a live attenuated strain. Veterinary Immunology and Immunopathology. 154(3-4):138-144
- Zhang, M., Wu, H., Li, X., Yang, M., Chen, T., Wang, Q., Liu, Q., and Zhang, Y. (2012) Edwardsiella tarda flagellar protein FlgD: A protective immunogen against edwardsiellosis. Vaccine. 30(26):3849-3856
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