Gene
rbp3
- ID
- ZDB-GENE-990415-132
- Name
- retinol binding protein 3
- Symbol
- rbp3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables all-trans-retinol binding activity and oleic acid binding activity. Predicted to act upstream of or within proteolysis. Is expressed in pineal complex and visual system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 66. Orthologous to human RBP3 (retinol binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11103 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 66 | Alliance | ?Retinitis pigmentosa 66 | 615233 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ClpP/crotonase-like domain superfamily | Tail specific protease |
|---|---|---|---|---|
| UniProtKB:A0A8M6Z8V0 | InterPro | 1201 | ||
| UniProtKB:F1Q9N9 | InterPro PDB | 615 | ||
| UniProtKB:A0A8M3B762 | InterPro | 523 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-77E10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131451 (1) | 2385 nt | ||
| Genomic | GenBank:CR450691 (1) | 157371 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z8V0 (1) | 1201 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | RBP3 | 10 | Amino acid sequence comparison (1) |
- Xie, J., Bui, B.V., Goodbourn, P.T., Jusuf, P.R. (2024) EFEMP1 contributes to light-dependent ocular growth in zebrafish. Biology Open. 13(12):
- Xie, J., Goodbourn, P.T., Bui, B.V., Jusuf, P.R. (2024) Establishment and comprehensive characterization of a novel dark-reared zebrafish model for myopia studies. Experimental Eye Research. 246:110009
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Schredelseker, T., Driever, W. (2018) Bsx controls pineal complex development. Development (Cambridge, England). 145(13):
- Sandoval, I.T., Delacruz, R.G., Miller, B.N., Hill, S., Olson, K.A., Gabriel, A.E., Boyd, K., Satterfield, C., Remmen, H.V., Rutter, J., Jones, D.A. (2017) A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).. eLIFE. 6
- Ghosh, D., Haswell, K.M., Sprada, M., Gonzalez-Fernandez, F. (2016) Fold conservation and proteolysis in zebrafish IRBP structure: Clues to possible enzymatic function?. Experimental Eye Research. 147:78-84
- Pinto, C.L., Kalasekar, S.M., McCollum, C.W., Riu, A., Jonsson, P., Lopez, J., Swindell, E., Bouhlatouf, A., Balaguer, P., Bondesson, M., Gustafsson, J.Å. (2016) Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Molecular and Cellular Endocrinology. 419:29-43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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