Gene
hoxc8a
- ID
- ZDB-GENE-990415-114
- Name
- homeobox C8a
- Symbol
- hoxc8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis; endocrine pancreas development; and exocrine pancreas development. Predicted to be active in nucleus. Is expressed in several structures, including endocrine system; fin; mesoderm; nervous system; and somite. Orthologous to human HOXC8 (homeobox C8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb341 (16 images)
- IMAGE:7162226 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxc8a | Maeno et al., 2024 | |
| MO1-hoxc8a | N/A | Sundaramoorthi et al., 2023 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Antp homeobox transcription factor | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q68EH7 | InterPro | 250 | ||||||
| UniProtKB:B2GTK2 | InterPro | 250 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxc8a-201
(1)
|
Ensembl | 1,186 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81P22 | ZFIN Curated Data | |
| Encodes | EST | cb341 | Thisse et al., 2001 | |
| Encodes | EST | IMAGE:7162226 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:91832 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193011 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005771 (1) | 2320 nt | ||
| Genomic | GenBank:BX005254 (1) | 160012 nt | ||
| Polypeptide | UniProtKB:B2GTK2 (1) | 250 aa |
- Adachi, U., Koita, R., Seto, A., Maeno, A., Ishizu, A., Oikawa, S., Tani, T., Ishizaka, M., Yamada, K., Satoh, K., Nakazawa, H., Furudate, H., Kawakami, K., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins. Proceedings of the National Academy of Sciences of the United States of America. 121:e2403809121e2403809121
- Maeno, A., Koita, R., Nakazawa, H., Fujii, R., Yamada, K., Oikawa, S., Tani, T., Ishizaka, M., Satoh, K., Ishizu, A., Sugawara, T., Adachi, U., Kikuchi, M., Iwanami, N., Matsuda, M., Kawamura, A. (2024) Hox code responsible for the pattering of the anterior vertebrae in zebrafish. Development (Cambridge, England). 151(14):
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Xue, S., Ly, T.T.N., Vijayakar, R.S., Chen, J., Ng, J., Mathuru, A.S., Magdinier, F., Reversade, B. (2022) HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature communications. 13:3583
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Lu, J.K., Tsai, T.C., Lee, H., Hsia, K., Lin, C.H., Lu, J.H. (2019) Pectoral Fin Anomalies in tbx5a Knockdown Zebrafish Embryos Related to the Cascade Effect of N-Cadherin and Extracellular Matrix Formation. Journal of developmental biology. 7(3)
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Wang, J., Fei, F., Berberoglu, M.A., Sun, S., Wang, L., Dong, Z., Wang, X. (2018) Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis. Journal of molecular cell biology. 10(6):586-588
- Yu, C., Yao, X., Zhao, L., Wang, P., Zhang, Q., Zhao, C., Yao, S., Wei, Y. (2017) Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation. Neoplasia (New York, N.Y.). 19:606-616
- San, B., Chrispijn, N.D., Wittkopp, N., van Heeringen, S.J., Lagendijk, A.K., Aben, M., Bakkers, J., Ketting, R.F., Kamminga, L.M. (2016) Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports. 6:24658
1 - 10 of 40
Show