Gene

smo

ID
ZDB-GENE-980526-89
Name
smoothened, frizzled class receptor
Symbol
smo Nomenclature History
Previous Names
  • CHUNP6862
  • slow muscle omitted
  • smoh
  • smoothened (1)
  • smu
  • wu:fb70b01
  • wu:fc39h03
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Exhibits oxysterol binding activity. Involved in several processes, including animal organ development; blood vessel development; and nervous system development. Localizes to cilium. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Orthologous to human SMO (smoothened, frizzled class receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
104 figures from 65 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smo Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Basal cell carcinoma, somatic 605462
Curry-Jones syndrome, somatic mosaic 601707
Pallister-Hall-like syndrome 241800
Associated With smo Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Domain IPR020067 Frizzled domain
Domain IPR035683 Smoothened, transmembrane domain
Domain IPR041771 Smoothened, cysteine-rich domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026544 Smoothened
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like Smoothened Smoothened, cysteine-rich domain Smoothened, transmembrane domain
UniProtKB:Q90YY4 808
UniProtKB:Q5RH73 822
UniProtKB:Q90X26 822
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations