Gene

hoxb5a

ID

ZDB-GENE-980526-70

Name

homeobox B5a

Symbol

hoxb5a Nomenclature History

Previous Names

hox-2.1
hox-B5
hoxb5
wu:fc38c09
z-18
ZF-21
ZF21

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development and cell fate specification. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesenchyme; mesoderm; neural tube; and somite. Orthologous to human HOXB5 (homeobox B5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 23 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu480 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Maeno et al., 2024
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hoxb5a Human Ortholog

No data available

Associated With hoxb5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001827	Homeobox protein, antennapedia type, conserved site
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR017995	Homeobox protein, antennapedia type
Family	IPR050296	Antennapedia-type homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily