tgfbr2b

ID

ZDB-GENE-980526-375

Name

transforming growth factor beta receptor 2b

Symbol

tgfbr2b Nomenclature History

Previous Names

tgfbr2
cb537 (1)
TGF-beta receptor 2
wu:fj05c10
zgc:110498 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable several functions, including activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including activin receptor signaling pathway; cellular response to growth factor stimulus; and heart development. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and trigeminal ganglion. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb537 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Monteiro et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tgfbr2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
esophageal cancer	Alliance	Esophageal cancer, somatic	133239
hereditary nonpolyposis colorectal cancer type 6	Alliance	Colorectal cancer, hereditary nonpolyposis, type 6	614331
Loeys-Dietz syndrome 2	Alliance	Loeys-Dietz syndrome 2	610168

Associated With tgfbr2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR015013	Transforming growth factor beta receptor 2 ectodomain
Family	IPR000333	Ser/Thr protein kinase, TGFB receptor
Family	IPR017194	Transforming growth factor-beta receptor, type II
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR045860	Snake toxin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q58EQ1	InterPro	556
UniProtKB:A0AC58HFB6	InterPro	570
UniProtKB:A0AC58HFC2	InterPro	570
UniProtKB:A0AC58HFC3	InterPro	570
UniProtKB:A0AC58HFC4	InterPro	570
UniProtKB:A0AC58HFC6	InterPro	570
UniProtKB:A0AC58HFC7	InterPro	570
UniProtKB:A0AC58HFC8	InterPro	570
UniProtKB:A0AC58HFD0	InterPro	570
UniProtKB:A0AC58HFD1	InterPro	570
UniProtKB:A0AC58HFD2	InterPro	570
UniProtKB:A0AC58HFD3	InterPro	570
UniProtKB:A0AC58HFD4	InterPro	570
UniProtKB:A0AC58HFD6	InterPro	570
UniProtKB:A0AC58HFD7	InterPro	570
UniProtKB:A0AC58HFD9	InterPro	570
UniProtKB:A0AC58HFE0	InterPro	570
UniProtKB:A0AC58HFE1	InterPro	570
UniProtKB:A0AC58HFE4	InterPro	570
UniProtKB:A0AC58HFE6	InterPro	502
UniProtKB:A0AC58HFE8	InterPro	570
UniProtKB:A0AC58HFE9	InterPro	536
UniProtKB:A0AC58HFF1	InterPro	570
UniProtKB:A0AC58HFF3	InterPro	570
UniProtKB:A0AC58HFF9	InterPro	383
UniProtKB:A0AC58HFG5	InterPro	570
UniProtKB:A0AC58HFG8	InterPro	570
UniProtKB:A0AC58HFH5	InterPro	570
UniProtKB:A0AC58HFI5	InterPro	455