Gene
ikzf1
- ID
- ZDB-GENE-980526-304
- Name
- IKAROS family zinc finger 1 (Ikaros)
- Symbol
- ikzf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 79 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu522 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Hess et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Immunodeficiency, common variable, 13 | 616873 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:A0A2R8Q9J3
|
424 | ||
|
UniProtKB:B8A604
|
294 | ||
|
UniProtKB:B8A605
|
392 | ||
|
UniProtKB:A0A2R8Q8T6
|
516 | ||
|
UniProtKB:Q90XA0
|
294 | ||
|
UniProtKB:Q90XA2
|
434 | ||
|
UniProtKB:B8A607
|
526 | ||
|
UniProtKB:Q90XA3
|
526 | ||
|
UniProtKB:B8A606
|
434 | ||
|
UniProtKB:B8A603
|
537 | ||
|
UniProtKB:Q90XA1
|
392 | ||
|
UniProtKB:O93581
|
537 |
Interactions and Pathways
No data available
Plasmids