Gene
ikzf1
- ID
- ZDB-GENE-980526-304
- Name
- IKAROS family zinc finger 1 (Ikaros)
- Symbol
- ikzf1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 70 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu522 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| common variable immunodeficiency 13 | Alliance | Immunodeficiency, common variable, 13 | 616873 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ikaros C2H2-type zinc-finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3C7 | InterPro | 641 | |||
| UniProtKB:A0A8M2B3I1 | InterPro | 496 | |||
| UniProtKB:O93581 | InterPro | 537 | |||
| UniProtKB:A0A8M3AZ03 | InterPro | 599 | |||
| UniProtKB:A0A8M2B2R4 | InterPro | 588 | |||
| UniProtKB:A0A8M2B2X4 | InterPro | 538 | |||
| UniProtKB:A0A8M2B2N6 | InterPro | 630 | |||
| UniProtKB:A0AB32U5P9 | InterPro | 549 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ikzf1-201
(1)
|
Ensembl | 2,301 nt | ||
| mRNA |
ikzf1-202
(1)
|
Ensembl | 1,219 nt | ||
| mRNA |
ikzf1-203
(1)
|
Ensembl | 1,513 nt | ||
| mRNA |
ikzf1-204
(1)
|
Ensembl | 1,639 nt | ||
| mRNA |
ikzf1-205
(1)
|
Ensembl | 1,915 nt | ||
| mRNA |
ikzf1-206
(1)
|
Ensembl | 2,530 nt | ||
| mRNA |
ikzf1-207
(1)
|
Ensembl | 2,254 nt | ||
| mRNA |
ikzf1-208
(1)
|
Ensembl | 1,614 nt |
Interactions and Pathways
No data available
Plasmids