ZFIN is now using GRCz12tu for Genomic Data
Gene
ptch1
- ID
- ZDB-GENE-980526-196
- Name
- patched 1
- Symbol
- ptch1 Nomenclature History
- Previous Names
-
- ptc2
- lep
- leprechaun
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hedgehog receptor activity. Acts upstream of or within several processes, including intramembranous ossification; negative regulation of smoothened signaling pathway; and osteoblast differentiation. Predicted to be located in membrane. Is expressed in several structures, including cranium; digestive system; epithelium; mesenchyme; and nervous system. Human ortholog(s) of this gene implicated in carcinoma (multiple); holoprosencephaly (multiple); nevoid basal cell carcinoma syndrome (multiple); and stomach cancer. Orthologous to human PTCH1 (patched 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 55 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu578 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 12 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| holoprosencephaly 7 | Alliance | Holoprosencephaly 7 | 610828 |
| nevoid basal cell carcinoma syndrome 1 | Alliance | Basal cell nevus syndrome 1 | 109400 |
| Basal cell carcinoma, somatic | 605462 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | HMGCR/SNAP/NPC1-like, sterol-sensing domain | Sterol-sensing domain | Transmembrane receptor, patched |
|---|---|---|---|---|---|
| UniProtKB:F1R8E2 | InterPro | 1475 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance