ZFIN is now using GRCz12tu for Genomic Data
Gene
c5ar1
- ID
- ZDB-GENE-190430-1
- Name
- complement C5a receptor 1
- Symbol
- c5ar1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable complement component C5a receptor activity. Predicted to be involved in mRNA transcription by RNA polymerase II; positive regulation of ERK1 and ERK2 cascade; and positive regulation of epithelial cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and chemotaxis. Predicted to be located in apical part of cell and basolateral plasma membrane. Is expressed in brain. Orthologous to human C5AR1 (complement C5a receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Formyl peptide receptor-related | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:A0AB13AA32 | InterPro | 346 | |||
| UniProtKB:P0C7U5 | InterPro | 346 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001424032 (1) | 2083 nt | ||
| Genomic | GenBank:JBMGRA010000018 (1) | |||
| Polypeptide | UniProtKB:A0AB13AA32 (1) | 346 aa |
- Comparative Orthology
- Alliance
- Fernandes, D.C., Tambourgi, D.V. (2023) Complement System Inhibitory Drugs in a Zebrafish (Danio rerio) Model: Computational Modeling. International Journal of Molecular Sciences. 24(18):
- Lelieveld, L.T., Gerhardt, S., Maas, S., Zwiers, K.C., de Wit, C., Beijk, E.H., Ferraz, M.J., Artola, M., Meijer, A.H., Tudorache, C., Salvatori, D., Boot, R.G., Aerts, J.M.F.G. (2022) Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Journal of Lipid Research. 63(5):100199
- Sehring, I.M., Mohammadi, H.F., Haffner-Luntzer, M., Ignatius, A., Huber-Lang, M., Weidinger, G. (2022) Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. eLIFE. 11:
- Li, L., Yang, W., Shen, Y., Xu, X., Li, J. (2020) Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Molecular immunology. 128:235-248
- Li, L., Yang, W., Shen, Y., Xu, X., Li, J. (2020) The evolutionary analysis of complement component C5 and the gene co-expression network and putative interaction between C5a and C5a anaphylatoxin receptor (C5AR/CD88) in human and two Cyprinid fish. Developmental and comparative immunology. 116:103958
- Natarajan, N., Abbas, Y., Bryant, D.M., Gonzalez-Rosa, J.M., Sharpe, M., Uygur, A., Cocco-Delgado, L.H., Ho, N.N., Gerard, N.P., Gerard, C.J., Macrae, C.A., Burns, C.E., Burns, C.G., Whited, J.L., Lee, R.T. (2018) Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 137(20):2152-2165
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