acvr2bb

ID

ZDB-GENE-170621-5

Name

activin A receptor type 2Bb

Symbol

acvr2bb Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable activin binding activity and activin receptor activity. Predicted to be involved in activin receptor signaling pathway; cellular response to growth factor stimulus; and pattern specification process. Predicted to act upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway and protein phosphorylation. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Preiß et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With acvr2bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy 4	Alliance	Heterotaxy, visceral, 4, autosomal	613751

Associated With acvr2bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000472	Activin types I and II receptor domain
Domain	IPR000719	Protein kinase domain
Family	IPR000333	Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR045860	Snake toxin-like superfamily