Gene

mfrp

ID
ZDB-GENE-160728-150
Name
membrane frizzled-related protein
Symbol
mfrp Nomenclature History
Previous Names
  • si:cabz01033205.3 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Acts upstream of or within eye development. Predicted to be located in plasma membrane. Is expressed in ciliated epithelial cell and retinal pigmented epithelium. Used to study hyperopia and microphthalmia. Human ortholog(s) of this gene implicated in isolated microphthalmia 5; microphthalmia; nanophthalmos; and retinitis pigmentosa. Orthologous to human MFRP (membrane frizzled-related protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Collery et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Collery et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
mw76Allele with one deletionExon 5UnknownCRISPR
mw77Allele with one delinsExon 5UnknownCRISPR
mw78Allele with one deletionExon 8UnknownCRISPR
mw79Allele with one delinsExon 8UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-mfrpCollery et al., 2016
CRISPR2-mfrp (2)
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Human Disease
Associated With mfrp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 5 Alliance Microphthalmia, isolated 5 611040
nanophthalmos Alliance Nanophthalmos 2 609549
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Associated With mfrp Via Experimental Models
Human Disease Fish Conditions Citations
microphthalmia mfrpmw78/mw78 standard conditions Collery et al., 2016
hyperopia mfrpmw78/mw78 standard conditions Collery et al., 2016
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Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000859 CUB domain
Domain IPR020067 Frizzled domain
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length CUB domain Frizzled cysteine-rich domain superfamily Frizzled domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Spermadhesin, CUB domain superfamily
UniProtKB:F1QRG7 InterPro 572
UniProtKB:A0A8M3B0L4 InterPro 311
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:cabz01033205.3-201 (1)
Ensembl
Ensembl 2,389 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
No data available
Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_009291315 (1)
ZFIN BLASTNCBI BLASTMegaBLASTEnsemblUCSC BLAT
GenomicGenBank:CABZ01033205 (1)25687 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:F1QRG7 (1)572 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMFRP11
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
MouseMfrp9
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
TSV
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