Gene

tomt

ID
ZDB-GENE-160629-1
Name
transmembrane O-methyltransferase
Symbol
tomt Nomenclature History
Previous Names
  • mercury (1)
  • mrc (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Is predicted to enable catechol O-methyltransferase activity. Involved in auditory behavior. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; neuromast development; and neuron differentiation. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in anterior macula; inner ear; neuromast hair cell; and posterior macula. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Erickson et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Erickson et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tomt Human Ortholog
No data available
Associated With tomt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002935 Class I-like SAM-dependent O-methyltransferase
Family IPR033025 Transmembrane O-methyltransferase
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length Class I-like SAM-dependent O-methyltransferase S-adenosyl-L-methionine-dependent methyltransferase Transmembrane O-methyltransferase
UniProtKB:A0A193KX02 259
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations