ZFIN is now using GRCz12tu for Genomic Data
Gene
tomt
- ID
- ZDB-GENE-160629-1
- Name
- transmembrane O-methyltransferase
- Symbol
- tomt Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable catechol O-methyltransferase activity. Involved in auditory behavior. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; neuromast development; and neuron differentiation. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in anterior macula; inner ear; neuromast hair cell; and posterior macula. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to human LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing) and TOMT (transmembrane O-methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Erickson et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Class I-like SAM-dependent O-methyltransferase | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
| UniProtKB:A0A8M9PLX8 | InterPro | 259 | ||
| UniProtKB:A0A193KX02 | InterPro | 259 | ||
| UniProtKB:A0AB13ABH8 | InterPro | 259 | ||
| UniProtKB:A0AB32T7Z5 | InterPro | 317 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers