ZFIN is now using GRCz12tu for Genomic Data
Gene
iqgap3
- ID
- ZDB-GENE-160226-1
- Name
- IQ motif containing GTPase activating protein 3
- Symbol
- iqgap3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activator activity; actin filament binding activity; and calmodulin binding activity. Acts upstream of or within cell motility and convergent extension involved in gastrulation. Predicted to be located in plasma membrane bounded cell projection. Predicted to be active in cell cortex. Is expressed in digestive system; pectoral fin bud; pharyngeal arch; sensory system; and ventricular zone. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nonsyndromic deafness | s356tTg + MO2-iqgap3 | control | Li et al., 2025 |
| nonsyndromic deafness | WT + MO2-iqgap3 | control | Li et al., 2025 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Conserved_site | IPR023152 | Ras GTPase-activating protein, conserved site |
| Domain | IPR000593 | RasGAP protein, C-terminal |
| Domain | IPR001202 | WW domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001936 | Ras GTPase-activating domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | IQ motif, EF-hand binding site | RasGAP protein, C-terminal | Ras GTPase-activating domain | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | WW domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0F7EVQ6 | InterPro | 1639 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
iqgap3-201
(1)
|
Ensembl | 4,920 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers