Gene
dchs2
- ID
- ZDB-GENE-150311-2
- Name
- dachsous cadherin-related 2
- Symbol
- dchs2 Nomenclature History
- Previous Names
-
- si:dkey-30k22.7
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within cartilage morphogenesis. Predicted to be located in membrane. Is expressed in Meckel's cartilage and palatoquadrate cartilage. Orthologous to human DCHS2 (dachsous cadherin-related 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9493 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19501 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19502 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39615 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| stl1 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko486a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko486b | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cadherin conserved site | Cadherin domain-containing protein | Cadherin-like | Cadherin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AGZ3 | InterPro | 3264 | ||||
| UniProtKB:A0A8M9QEM9 | InterPro | 3264 | ||||
| UniProtKB:A0A8M6YZ39 | InterPro | 1786 | ||||
| UniProtKB:A0A8M9Q9E9 | InterPro | 1786 | ||||
| UniProtKB:A0AB32THB6 | InterPro | 3284 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-30k22.7-201
(1)
|
Ensembl | 3,610 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-30K22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221269 (1) | 10880 nt | ||
| Genomic | GenBank:AL935184 (1) | 255909 nt | ||
| Polypeptide | UniProtKB:A0AB32THB6 (1) | 3284 aa |
- Comparative Orthology
- Alliance
- Paz, D., Pinales, B.E., Castellanos, B.S., Perez, I., Gil, C.B., Madrigal, L.J., Reyes-Nava, N.G., Castro, V.L., Sloan, J.L., Quintana, A.M. (2023) Abnormal chondrocyte development in a zebrafish model of cblC syndrome restored by an MMACHC cobalamin binding mutant. Differentiation; research in biological diversity. 131:748174-81
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Chen, J., Castelvecchi, G.D., Li-Villarreal, N., Raught, B., Krezel, A.M., McNeill, H., Solnica-Krezel, L. (2018) Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages. Developmental Cell. 45:376-391.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Li-Villarreal, N., Forbes, M.M., Loza, A.J., Chen, J., Ma, T., Helde, K., Moens, C.B., Shin, J., Sawada, A., Hindes, A.E., Dubrulle, J., Schier, A.F., Longmore, G.D., Marlow, F.L., Solnica-Krezel, L. (2015) Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (Cambridge, England). 142(15):2704-18
- Le Pabic, P., Ng, C., Schilling, T.F. (2014) Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development. PLoS Genetics. 10:e1004726
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