ZFIN is now using GRCz12tu for Genomic Data
Gene
aifm3
- ID
- ZDB-GENE-140619-2
- Name
- AIF family member 3
- Symbol
- aifm3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable oxidoreductase activity, acting on NAD(P)H. Acts upstream of or within pronephros morphogenesis. Predicted to be active in mitochondrion.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lopez-Rivera et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR028202 | Reductase, C-terminal |
| Family | IPR050446 | FAD-dependent Oxidoreductases and Apoptosis Regulators |
| Homologous_superfamily | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-dependent Oxidoreductases and Apoptosis Regulators | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Reductase, C-terminal | Rieske [2Fe-2S] iron-sulphur domain | Rieske [2Fe-2S] iron-sulphur domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F2Z4R3 | InterPro | 599 | |||||||
| UniProtKB:A0A8M3B9D5 | InterPro | 598 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-98F17 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128413 (1) | 1800 nt | ||
| Genomic | GenBank:CR855305 (1) | 155542 nt | ||
| Polypeptide | UniProtKB:F2Z4R3 (2) | 599 aa |
- Campbell, P.D., Lee, I., Thyme, S., Granato, M. (2023) Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Molecular psychiatry. 28(9):3769-3781
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lopez-Rivera, E., Liu, Y.P., Verbitsky, M., Anderson, B.R., Capone, V.P., Otto, E.A., Yan, Z., Mitrotti, A., Martino, J., Steers, N.J., Fasel, D.A., Vukojevic, K., Deng, R., Racedo, S.E., Liu, Q., Werth, M., Westland, R., Vivante, A., Makar, G.S., Bodria, M., Sampson, M.G., Gillies, C.E., Vega-Warner, V., Maiorana, M., Petrey, D.S., Honig, B., Lozanovski, V.J., Salomon, R., Heidet, L., Carpentier, W., Gaillard, D., Carrea, A., Gesualdo, L., Cusi, D., Izzi, C., Scolari, F., van Wijk, J.A., Arapovic, A., Saraga-Babic, M., Saraga, M., Kunac, N., Samii, A., McDonald-McGinn, D.M., Crowley, T.B., Zackai, E.H., Drozdz, D., Miklaszewska, M., Tkaczyk, M., Sikora, P., Szczepanska, M., Mizerska-Wasiak, M., Krzemien, G., Szmigielska, A., Zaniew, M., Darlow, J.M., Puri, P., Barton, D., Casolari, E., Furth, S.L., Warady, B.A., Gucev, Z., Hakonarson, H., Flogelova, H., Tasic, V., Latos-Bielenska, A., Materna-Kiryluk, A., Allegri, L., Wong, C.S., Drummond, I.A., D'Agati, V., Imamoto, A., Barasch, J.M., Hildebrandt, F., Kiryluk, K., Lifton, R.P., Morrow, B.E., Jeanpierre, C., Papaioannou, V.E., Ghiggeri, G.M., Gharavi, A.G., Katsanis, N., Sanna-Cherchi, S. (2017) Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. The New England Journal of Medicine. 376(8):742-754
- Guna, A., Butcher, N.J., Bassett, A.S. (2015) Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Journal of neurodevelopmental disorders. 7:18
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