Gene
camkk2
- ID
- ZDB-GENE-140618-1
- Name
- calcium/calmodulin-dependent protein kinase kinase 2
- Symbol
- camkk2 Nomenclature History
- Previous Names
-
- si:ch73-62l21.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Is expressed in granule cell.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Takeuchi et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa39321 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-camkk2 | Xin et al., 2021 | |
| CRISPR2-camkk2 | Xin et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PDL9 | InterPro | 295 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-62l21.1-202
(1)
|
Ensembl | 478 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-62L21 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469223 (1) | 1061 nt | ||
| Genomic | GenBank:CU694957 (1) | 38437 nt | ||
| Polypeptide | UniProtKB:A0A8M9PDL9 (1) | 295 aa |
- Comparative Orthology
- Alliance
- Xin, Y., Guan, J., Li, Y., Duan, C. (2021) Regulation of cell quiescence-proliferation balance by Ca2+-CaMKK-Akt signaling. Journal of Cell Science. 134(20):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Huang, X., Zhao, Y., Liu, L., Fan, Z., Zhou, L., Wang, Z., Wei, L., Wang, D., Wei, J. (2016) Characterization of the POU5F1 homologue in Nile tilapia: from expression pattern to biological activity. Stem cells and development. 25(18):1386-95
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, R., Li, M., Li, Z., Hong, N., Xu, H., Hong, Y. (2015) Medaka Oct4 is Essential for Pluripotency in Blastula Formation and ES Cell Derivation. Stem cell reviews. 11(1):11-23
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