Gene
kcnab2a
- ID
- ZDB-GENE-140515-2
- Name
- potassium voltage-gated channel subfamily A regulatory beta subunit 2a
- Symbol
- kcnab2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable alcohol dehydrogenase (NADP+) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in several cellular components, including axon; cytoskeleton; and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2).
- Genome Resources
- Note
-
this gene corresponds to ENSDARG00000087247. No other sequence is currently available.
- Comparative Information
-
- All Expression Data
- 1 figure from Watanabe et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR023210 | NADP-dependent oxidoreductase domain |
Family | IPR005399 | Potassium channel, voltage-dependent, beta subunit, KCNAB-related |
Family | IPR005400 | Potassium channel, voltage-dependent, beta subunit, KCNAB1 |
Family | IPR005401 | Potassium channel, voltage-dependent, beta subunit, KCNAB2 |
Family | IPR005983 | Potassium channel, voltage-dependent, beta subunit, KCNAB |
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Domain Details Per Protein
Protein | Additional Resources | Length | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily | Potassium channel, voltage-dependent, beta subunit, KCNAB | Potassium channel, voltage-dependent, beta subunit, KCNAB1 | Potassium channel, voltage-dependent, beta subunit, KCNAB2 | Potassium channel, voltage-dependent, beta subunit, KCNAB-related |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3BDW0 | InterPro | 367 | ||||||
UniProtKB:A0A8M3B738 | InterPro | 353 | ||||||
UniProtKB:A0A8M9QM51 | InterPro | 430 | ||||||
UniProtKB:A0A8M3AXY2 | InterPro | 397 | ||||||
UniProtKB:A0AB32U100 | InterPro | 353 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
kcnab2a-201
(1)
|
Ensembl | 1,587 nt | ||
mRNA |
kcnab2a-202
(1)
|
Ensembl | 1,708 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-220D24 | ZFIN Curated Data | |
Contained in | BAC | DKEYP-123H11 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068224439 (1) | 2114 nt | ||
Genomic | GenBank:BX571706 (1) | 196333 nt | ||
Polypeptide | UniProtKB:A0A8M9QM51 (1) | 430 aa |
- Comparative Orthology
- Alliance
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Watanabe, T., Shimazaki, T., Mishiro, A., Suzuki, T., Hirata, H., Tanimoto, M., and Oda, Y. (2014) Coexpression of auxiliary Kvbeta2 subunits with Kv1.1 channels is required for developmental acquisition of unique firing properties of zebrafish Mauthner cells. Journal of neurophysiology. 111(6):1153-64
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