Gene

kcnab2a

ID
ZDB-GENE-140515-2
Name
potassium voltage-gated channel subfamily A regulatory beta subunit 2a
Symbol
kcnab2a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable alcohol dehydrogenase (NADP+) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in several cellular components, including axon; cytoskeleton; and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2).
Genome Resources
Note
this gene corresponds to ENSDARG00000087247. No other sequence is currently available.
Comparative Information
Expression
All Expression Data
1 figure from Watanabe et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa21974Allele with one point mutationUnknownPremature StopENU
sa41909Allele with one point mutationUnknownSplice SiteENU
sa44747Allele with one point mutationUnknownUnknownENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With kcnab2a Human Ortholog
No data available
Associated With kcnab2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR023210 NADP-dependent oxidoreductase domain
Family IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
Family IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
Family IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
Family IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
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Domain Details Per Protein
Protein Additional Resources Length NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily Potassium channel, voltage-dependent, beta subunit, KCNAB Potassium channel, voltage-dependent, beta subunit, KCNAB1 Potassium channel, voltage-dependent, beta subunit, KCNAB2 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
UniProtKB:A0A8M3BDW0 InterPro 367
UniProtKB:A0A8M3B738 InterPro 353
UniProtKB:A0A8M9QM51 InterPro 430
UniProtKB:A0A8M3AXY2 InterPro 397
UniProtKB:A0AB32U100 InterPro 353
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA kcnab2a-201 (1) Ensembl 1,587 nt
mRNA kcnab2a-202 (1) Ensembl 1,708 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-220D24ZFIN Curated Data
Contained inBACDKEYP-123H11ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanKCNAB21
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
MouseKcnab24
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations