Gene
trpc3
- ID
- ZDB-GENE-140129-1
- Name
- transient receptor potential cation channel, subfamily C, member 3
- Symbol
- trpc3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from von Niederhäusern et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa40313 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cerebellar ataxia type 41 | Alliance | ?Spinocerebellar ataxia 41 | 616410 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR005821 | Ion transport domain |
Domain | IPR013555 | Transient receptor ion channel domain |
Family | IPR002153 | Transient receptor potential channel, canonical |
Family | IPR005459 | Transient receptor potential channel, canonical 3 |
Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical | Transient receptor potential channel, canonical 3 |
---|---|---|---|---|---|---|---|---|
UniProtKB:U3N8Z0 | InterPro | 838 | ||||||
UniProtKB:A0A8M1P0G4 | InterPro | 902 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-370D1 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001289884 (1) | 2859 nt | ||
Genomic | GenBank:FP102983 (1) | 91094 nt | ||
Polypeptide | UniProtKB:A0A8M1P0G4 (1) | 902 aa |
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- von Niederhäusern, V., Kastenhuber, E., Stäuble, A., Gesemann, M., and Neuhauss, S.C. (2013) Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(12):1427-41
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