Gene

msh5

ID
ZDB-GENE-131127-632
Name
mutS homolog 5
Symbol
msh5 Nomenclature History
Previous Names
  • si:ch73-156o22.1 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-dependent ATPase activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to localize to nuclear chromosome. Human ortholog(s) of this gene implicated in premature ovarian failure. Orthologous to human MSH5 (mutS homolog 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With msh5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ovarian insufficiency 13 Alliance ?Premature ovarian failure 13 617442
Spermatogenic failure 74 619937
Associated With msh5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000432 DNA mismatch repair protein MutS, C-terminal
Domain IPR007696 DNA mismatch repair protein MutS, core
Domain IPR007861 DNA mismatch repair protein MutS, clamp
Family IPR011184 DNA mismatch repair Msh2-type
Family IPR045076 DNA mismatch repair MutS family
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036187 DNA mismatch repair protein MutS, core domain superfamily
Domain Details Per Protein
Protein Length DNA mismatch repair Msh2-type DNA mismatch repair MutS family DNA mismatch repair protein MutS, clamp DNA mismatch repair protein MutS, core DNA mismatch repair protein MutS, core domain superfamily DNA mismatch repair protein MutS, C-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:X1WGV2 789
UniProtKB:A0A2R8S0E2 516
UniProtKB:E7F6L5 572
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations