Gene
terf2ip
- ID
- ZDB-GENE-131121-641
- Name
- telomeric repeat binding factor 2, interacting protein
- Symbol
- terf2ip Nomenclature History
- Previous Names
-
- RAP1 (1)
- zmp:0000000584
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable telomeric DNA binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; regulation of nucleobase-containing compound metabolic process; and telomere maintenance. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wagner et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11124 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | Homedomain-like superfamily | TE2IP/Rap1 | TERF2-interacting telomeric protein 1, Myb domain | TRF2-interacting telomeric protein/Rap1, C-terminal | TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5S4 | InterPro | 610 | |||||||
| UniProtKB:Q6NYJ3 | InterPro | 616 | |||||||
| UniProtKB:A0A8M1P1Q7 | InterPro | 616 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
terf2ip-201
(1)
|
Ensembl | 1,725 nt | ||
| mRNA |
terf2ip-202
(1)
|
Ensembl | 2,481 nt | ||
| mRNA |
terf2ip-203
(1)
|
Ensembl | 2,565 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-214B20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001202416 (1) | |||
| Genomic | GenBank:CU481774 (1) | 37873 nt | ||
| Polypeptide | UniProtKB:A0A8M1P1Q7 (1) | 616 aa |
No data available
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Hu, X., Gao, S., Wang, P., Zhou, Y., Chen, K., Chen, Q., Wang, B., Hu, W., Cheng, P., Eid, R., Giraud-Panis, M.J., Wang, L., Gilson, E., Ye, J., Lu, Y. (2021) The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line. Biochimie. 190:12-19
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Wagner, K.D., Ying, Y., Leong, W., Jiang, J., Hu, X., Chen, Y., Michiels, J.F., Lu, Y., Gilson, E., Wagner, N., Ye, J. (2017) The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Aging. 9(4):1219-1232
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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