ZFIN is now using GRCz12tu for Genomic Data
Gene
pdgfbb
- ID
- ZDB-GENE-131121-332
- Name
- platelet-derived growth factor beta polypeptide b
- Symbol
- pdgfbb Nomenclature History
- Previous Names
-
- sb:eu2436
- si:dkey-110g7.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including angiogenesis; platelet-derived growth factor receptor signaling pathway; and positive regulation of intracellular signal transduction. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2436 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| Meningioma, SIS-related | 607174 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PEQ6 | InterPro | 483 | |||
| UniProtKB:A0A2R8Q0D8 | InterPro | 483 | |||
| UniProtKB:A0A8M9PWR6 | InterPro | 482 | |||
| UniProtKB:A0A8M9PRI9 | InterPro | 482 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfbb-201
(1)
|
Ensembl | 3,821 nt | ||
| mRNA |
pdgfbb-202
(1)
|
Ensembl | 4,898 nt | ||
| mRNA |
pdgfbb-203
(1)
|
Ensembl | 7,212 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers