Gene
klhl10b.1
- ID
- ZDB-GENE-131015-2
- Name
- kelch-like family member 10b, tandem duplicate 1
- Symbol
- klhl10b.1 Nomenclature History
- Previous Names
-
- klhl10b
- si:ch211-278p9.8
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 11 | Alliance | Spermatogenic failure 11 | 615081 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/Kelch-associated | BTB-kelch protein | BTB/POZ domain | Kelch-like protein 10, BTB/POZ domain | Kelch repeat type 1 | Kelch-type beta propeller | SKP1/BTB/POZ domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PEI5 | InterPro | 555 | |||||||
| UniProtKB:A0A8M9PNX9 | InterPro | 581 | |||||||
| UniProtKB:A0AB32TNT3 | InterPro | 1175 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
klhl10b.1-201
(1)
|
Ensembl | 1,845 nt | ||
| mRNA |
klhl10b.1-202
(1)
|
Ensembl | 1,845 nt | ||
| mRNA |
klhl10b.1-203
(1)
|
Ensembl | 1,809 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278P9 | ||
| Contained in | BAC | DKEY-238G8 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068218845 (1) | 3611 nt | ||
| Genomic | GenBank:BX005013 (1) | 164864 nt | ||
| Polypeptide | UniProtKB:A0AB32TNT3 (1) | 1175 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | KLHL10 | 17 | Amino acid sequence comparison (1) |
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Feiner, N., Murakami, Y., Breithut, L., Mazan, S., Meyer, A., and Kuraku, S. (2013) Saltatory evolution of the ectodermal neural cortex (ENC) gene family at the vertebrate origin. Genome biology and evolution. 5(8):1485-502
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