Gene

kcnj10a

ID

ZDB-GENE-130726-1

Name

potassium inwardly rectifying channel subfamily J member 10a

Symbol

kcnj10a Nomenclature History

Previous Names

Kir4.1a (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits inward rectifier potassium channel activity. Involved in kidney development; larval locomotory behavior; and swimming. Predicted to localize to integral component of membrane. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Is expressed in several structures, including central nervous system; opercular flap; pleuroperitoneal region; retinal inner nuclear layer; and scale. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnj10a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 4	Alliance	Enlarged vestibular aqueduct, digenic	600791
EAST syndrome	Alliance	SESAME syndrome	612780

Associated With kcnj10a Via Experimental Models

Human Disease	Fish	Conditions	Citations
EAST syndrome	TL + MO1-kcnj10a	standard conditions	Mahmood et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain
Domain	IPR041647	Inward rectifier potassium channel, C-terminal
Family	IPR003268	FPotassium channel, inwardly rectifying, Kir1.1
Family	IPR016449	Potassium channel, inwardly rectifying, Kir
Homologous_superfamily	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily	IPR014756	Immunoglobulin E-set