Gene

si:ch211-216b21.2

ID

ZDB-GENE-130603-96

Name

si:ch211-216b21.2

Symbol

si:ch211-216b21.2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase activity. Predicted to be located in Golgi membrane.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Marchegiani et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With si:ch211-216b21.2 Human Ortholog

No data available

Associated With si:ch211-216b21.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000863	Sulfotransferase domain
Family	IPR037359	Heparan sulfate sulfotransferase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

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Domain Details Per Protein

Protein	Additional Resources	Length	Heparan sulfate sulfotransferase	P-loop containing nucleoside triphosphate hydrolase	Sulfotransferase domain
UniProtKB:E7F3X3	InterPro	399

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 12

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:ch211-216b21.2-201 (1) Ensembl	Ensembl		4,621 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-216b21.2-202 (1) Ensembl	Ensembl		962 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-216B21	CR749163	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_002664008 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CR749163 (1)	189369 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F3X3 (1)	399 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

No data available

Citations

Include unpublished citations

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110

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