Gene
dlc1
- ID
- ZDB-GENE-130206-12
- Name
- DLC1 Rho GTPase activating protein
- Symbol
- dlc1 Nomenclature History
- Previous Names
-
- unm_sa1141
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity and lipid binding activity. Predicted to be involved in regulation of Rho protein signal transduction and signal transduction. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR002913 | START domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR023393 | START-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Rho GTPase-activating protein domain | Rho GTPase activation protein | START domain | START-like domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FBY0
|
|||||||
|
UniProtKB:A0A8M9PK49
|
1191 | ||||||
|
UniProtKB:A0A8M6Z677
|
1669 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance