ZFIN is now using GRCz12tu for Genomic Data
Gene
efl1
- ID
- ZDB-GENE-130103-6
- Name
- elongation factor like GTPase 1
- Symbol
- efl1 Nomenclature History
- Previous Names
-
- eftud1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cytosolic ribosome assembly. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Shwachman-Diamond syndrome 2 | 617941 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000640 | Elongation factor EFG, domain V-like |
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR005225 | Small GTP-binding domain |
| Domain | IPR041095 | Elongation Factor G, domain II |
| Domain | IPR056752 | Elongation factor-like GTPase 1 domain |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR035647 | EF-G domain III/V-like |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-G domain III/V-like | Elongation factor EFG, domain V-like | Elongation Factor G, domain II | Elongation factor-like GTPase 1 domain | P-loop containing nucleoside triphosphate hydrolase | Ribosomal protein uS5 domain 2-type superfamily | Small GTP-binding domain | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Translational (tr)-type GTP-binding domain | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4ITN4 | InterPro | 1133 | |||||||||||
| UniProtKB:A0AA70QSB6 | InterPro | 1115 | |||||||||||
| UniProtKB:A0AC58G383 | InterPro | 619 | |||||||||||
| UniProtKB:A0AC58G389 | InterPro | 619 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance