Gene

gan

ID
ZDB-GENE-121221-1
Name
gigaxonin
Symbol
gan Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including regulation of neuromuscular junction development; regulation of somitogenesis; and spinal cord motor neuron cell fate specification. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in eye; heart; muscle; and notochord. Human ortholog(s) of this gene implicated in giant axonal neuropathy 1. Orthologous to human GAN (gigaxonin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Arribat et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Arribat et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gan Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
giant axonal neuropathy 1 Alliance Giant axonal neuropathy-1 256850
1 - 1 of 1
Associated With gan Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR011705 BTB/Kelch-associated
Domain IPR030579 Gigaxonin, BACK domain
Domain IPR047070 Gigaxonin, BTB/POZ domain
Family IPR017096 BTB-kelch protein
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length BTB/Kelch-associated BTB-kelch protein BTB/POZ domain Gigaxonin, BACK domain Gigaxonin, BTB/POZ domain Kelch repeat type 1 Kelch-type beta propeller SKP1/BTB/POZ domain superfamily
UniProtKB:A0A2I4KBP1 InterPro 609
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gan-201 (1) Ensembl 1,578 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations