Gene
hdac5
- ID
- ZDB-GENE-121219-3
- Name
- histone deacetylase 5
- Symbol
- hdac5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable histone deacetylase activity. Acts upstream of or within pronephros morphogenesis. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC5 (histone deacetylase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Rothschild et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hdac5 | N/A | Just et al., 2011 |
| MO2-hdac5 | N/A | Huang et al., 2013 |
| MO3-hdac5 | N/A | Kaluza et al., 2013 |
| MO4-hdac5 | N/A | Rothschild et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023801 | Histone deacetylase domain |
| Domain | IPR024643 | Histone deacetylase, glutamine rich N-terminal domain |
| Family | IPR046949 | Histone deacetylase 4/5/7/9 |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Histone deacetylase 4/5/7/9 | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase, glutamine rich N-terminal domain | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PXQ8 | InterPro | 1068 | |||||
| UniProtKB:A0A8M3B885 | InterPro | 1125 | |||||
| UniProtKB:A0A8M9P8E1 | InterPro | 1067 | |||||
| UniProtKB:A0A8M3AQU0 | InterPro | 1085 | |||||
| UniProtKB:A0A8M3AQH0 | InterPro | 1127 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237I5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021471411 (1) | 9586 nt | ||
| Genomic | GenBank:BX901956 (1) | 197042 nt | ||
| Polypeptide | UniProtKB:E7FH14 (1) | 1128 aa |
- De Meulemeester, A.S., Heylen, L., Siekierska, A., Mills, J.D., Romagnolo, A., Van Der Wel, N.N., Aronica, E., de Witte, P.A.M. (2022) Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. Frontiers in cell and developmental biology. 10:952832
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Letelier, J., Terriente, J., Belzunce, I., Voltes, A., Undurraga, C.A., Polvillo, R., Devos, L., Tena, J.J., Maeso, I., Retaux, S., Gomez-Skarmeta, J.L., Martínez-Morales, J.R., Pujades, C. (2018) Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation.. Proceedings of the National Academy of Sciences of the United States of America. 115(16):E3731-E3740
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
- Rothschild, S.C., Lee, H.J., Ingram, S.R., Mohammadi, D.K., Walsh, G.S., Tombes, R.M. (2018) Calcium Signals Act Through Histone Deacetylase to Mediate Pronephric Kidney Morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(6):807-817
- Armant, O., Gombeau, K., Murat El Houdigui, S., Floriani, M., Camilleri, V., Cavalie, I., Adam-Guillermin, C. (2017) Zebrafish exposure to environmentally relevant concentration of depleted uranium impairs progeny development at the molecular and histological levels. PLoS One. 12:e0177932
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Kaluza, D., Kroll, J., Gesierich, S., Manavski, Y., Boeckel, J., Doebele, C., Zelent, A., Rossig, L., Zeiher, A. M., Augustin, H. G., Urbich, C., Dimmeler, S. (2013) Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells.. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:533-543
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