Gene
si:ch73-383l1.1
- ID
- ZDB-GENE-121214-64
- Name
- si:ch73-383l1.1
- Symbol
- si:ch73-383l1.1 Nomenclature History
- Previous Names
-
- erbb4d (1)
- si:ch73-162k10.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of epithelial cell proliferation. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in endomembrane system and membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa6573 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16410 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16469 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19414 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa24834 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa25517 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa32584 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa32585 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-si:ch73-383l1.1 | Sun et al., 2019 | |
CRISPR2-si:ch73-383l1.1 | Sun et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000494 | Receptor L-domain |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Epidermal growth factor receptor, juxtamembrane domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0A0MPK4 | InterPro | |||||||||||||||||
UniProtKB:A0A8M9Q7Y5 | InterPro | 1392 | ||||||||||||||||
UniProtKB:A0AB32TT21 | InterPro | 1373 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
erbb4-202
(1)
|
Ensembl | 4,596 nt | ||
mRNA |
si:ch73-383l1.1-202
(1)
|
Ensembl | 2,844 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-162K10 | ZFIN Curated Data | |
Contained in | BAC | CH73-383L1 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068220987 (1) | 12590 nt | ||
Genomic | GenBank:CU972514 (1) | 110190 nt | ||
Polypeptide | UniProtKB:A0A8M9Q7Y5 (1) | 1392 aa |
- Comparative Orthology
- Alliance
No data available
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Paatero, I., Veikkolainen, V., Mäenpää, M., Schmelzer, E., Belting, H.G., Pelliniemi, L.J., Elenius, K. (2018) ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos. Molecular biology of the cell. 30(2):209-218
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
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