Gene
jmjd1cb
- ID
- ZDB-GENE-121214-344
- Name
- jumonji domain containing 1Cb
- Symbol
- jmjd1cb Nomenclature History
- Previous Names
-
- si:dkey-204n14.2
- zmp:0000000876 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Acts upstream of or within myeloid cell development. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Predicted to be active in chromatin. Orthologous to human JMJD1C (jumonji domain containing 1C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gieger et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa6235 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11812 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15925 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18109 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22034 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-jmjd1cb | Brocal et al., 2016 | |
CRISPR2-jmjd1cb | Brocal et al., 2016 | |
MO1-jmjd1cb | N/A | Huang et al., 2013 |
MO2-jmjd1cb | N/A | Huang et al., 2013 |
MO3-jmjd1cb | N/A | Gieger et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Domain of unknown function DUF7030 | JmjC domain | Lysine-specific demethylase 3A/B, tudor domain | Lysine-specific demethylase 3B, PWWP domain |
---|---|---|---|---|---|---|
UniProtKB:A0A8M3B798 | InterPro | 2554 | ||||
UniProtKB:A0A8M3BE19 | InterPro | 2568 | ||||
UniProtKB:A0A8M6Z3J7 | InterPro | 2398 | ||||
UniProtKB:A0A8M2B2R0 | InterPro | 2558 | ||||
UniProtKB:A0A8M3B4G8 | InterPro | 2543 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
jmjd1cb-201
(1)
|
Ensembl | 8,751 nt | ||
mRNA |
jmjd1cb-203
(1)
|
Ensembl | 7,575 nt | ||
ncRNA |
jmjd1cb-002
(1)
|
Ensembl | 783 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-101C7 | ZFIN Curated Data | |
Contained in | BAC | DKEY-204N14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_068224728 (1) | 8801 nt | ||
Genomic | GenBank:CR354401 (1) | 168372 nt | ||
Polypeptide | UniProtKB:A0A8M3AY68 (1) | 2569 aa |
- Comparative Orthology
- Alliance
- Das, T., Soren, K., Yerasi, M., Kumar, A., Chakravarty, S. (2019) Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model. Neuroscience letters. 712:134492
- Fellous, A., Earley, R.L., Silvestre, F. (2018) The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene. 687:173-187
- Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
- Brocal, I., White, R.J., Dooley, C.M., Carruthers, S.N., Clark, R., Hall, A., Busch-Nentwich, E.M., Stemple, D.L., Kettleborough, R.N. (2016) Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics. 17:259
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Gieger, C., Radhakrishnan, A., Cvejic, A., Tang, W., Porcu, E., Pistis, G., Serbanovic-Canic, J., Elling, U., Goodall, A.H., Labrune, Y., Lopez, L.M., Mägi, R., Meacham, S., Okada, Y., Pirastu, N., Sorice, R., Teumer, A., Voss, K., Zhang, W., Ramirez-Solis, R., Bis, J.C., Ellinghaus, D., Gögele, M., Hottenga, J.J., Langenberg, C., Kovacs, P., O'Reilly, P.F., Shin, S.Y., Esko, T., Hartiala, J., Kanoni, S., Murgia, F., Parsa, A., Stephens, J., van der Harst, P., Ellen van der Schoot, C., Allayee, H., Attwood, A., Balkau, B., Bastardot, F., Basu, S., Baumeister, S.E., Biino, G., Bomba, L., Bonnefond, A., Cambien, F., Chambers, J.C., Cucca, F., D'Adamo, P., Davies, G., de Boer, R.A., de Geus, E.J., Döring, A., Elliott, P., Erdmann, J., Evans, D.M., Falchi, M., Feng, W., Folsom, A.R., Frazer, I.H., Gibson, Q.D., Glazer, N.L., Hammond, C., Hartikainen, A.L., Heckbert, S.R., Hengstenberg, C., Hersch, M., Illig, T., Loos, R.J., Jolley, J., Khaw, K.T., Kühnel, B., Kyrtsonis, M.C., Lagou, V., Lloyd-Jones, H., Lumley, T., Mangino, M., Maschio, A., Mateo Leach, I., McKnight, B., Memari, Y., Mitchell, B.D., Montgomery, G.W., Nakamura, Y., Nauck, M., Navis, G., Nöthlings, U., Nolte, I.M., Porteous, D.J., Pouta, A., Pramstaller, P.P., Pullat, J., Ring, S.M., Rotter, J.I., Ruggiero, D., Ruokonen, A., Sala, C., Samani, N.J., Sambrook, J., Schlessinger, D., Schreiber, S., Schunkert, H., Scott, J., Smith, N.L., Snieder, H., Starr, J.M., Stumvoll, M., Takahashi, A., Tang, W.H., Taylor, K., Tenesa, A., Lay Thein, S., Tönjes, A., Uda, M., Ulivi, S., van Veldhuisen, D.J., Visscher, P.M., Völker, U., Wichmann, H.E., Wiggins, K.L., Willemsen, G., Yang, T.P., Hua Zhao, J., Zitting, P., Bradley, J.R., Dedoussis, G.V., Gasparini, P., Hazen, S.L., Metspalu, A., Pirastu, M., Shuldiner, A.R., Joost van Pelt, L., Zwaginga, J.J., Boomsma, D.I., Deary, I.J., Franke, A., Froguel, P., Ganesh, S.K., Jarvelin, M.R., Martin, N.G., Meisinger, C., Psaty, B.M., Spector, T.D., Wareham, N.J., Akkerman, J.W., Ciullo, M., Deloukas, P., Greinacher, A., Jupe, S., Kamatani, N., Khadake, J., Kooner, J.S., Penninger, J., Prokopenko, I., Stemple, D., Toniolo, D., Wernisch, L., Sanna, S., Hicks, A.A., Rendon, A., Ferreira, M.A., Ouwehand, W.H., Soranzo, N. (2011) New gene functions in megakaryopoiesis and platelet formation. Nature. 480:201-8
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