Gene
mcoln3a
- ID
- ZDB-GENE-121116-4
- Name
- mucolipin TRP cation channel 3a
- Symbol
- mcoln3a Nomenclature History
- Previous Names
-
- mcoln3.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable NAADP-sensitive calcium-release channel activity. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in endosome membrane. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human MCOLN3 (mucolipin TRP cation channel 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Mucolipin | Mucolipin, extracytosolic domain | Polycystin cation channel, PKD1/PKD2 |
---|---|---|---|---|---|
UniProtKB:A0A8M9P7U6 | InterPro | 542 | |||
UniProtKB:E7FE44 | InterPro | 541 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mcoln3a-201
(1)
|
Ensembl | 3,426 nt | ||
mRNA |
mcoln3a-202
(1)
|
Ensembl | 1,626 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-169M11 | ||
Contained in | Fosmid | ZFOS-929E12 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_021466658 (1) | 3390 nt | ||
Genomic | GenBank:CU693488 (2) | 38603 nt | ||
Polypeptide | UniProtKB:A0A8M9P7U6 (1) | 542 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Benini, A., Bozzato, A., Mantovanelli, S., Calvarini, L., Giacopuzzi, E., Bresciani, R., Moleri, S., Zizioli, D., Beltrame, M., and Borsani, G. (2013) Characterization and expression analysis of mcoln1.1 and mcoln1.2, the putative zebrafish co-orthologs of the gene responsible for human mucolipidosis type IV. The International journal of developmental biology. 57(1):85-93
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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